TRMU O75648

线粒体tRNA特异性2-硫尿苷化酶1 (EC 2.8.1.14) (MTO2同源蛋白)

蛋白质信息 (UniProt)

线粒体tRNA特异性2-硫尿苷化酶1 (EC 2.8.1.14) (MTO2同源蛋白)

O75648

功能描述

催化线粒体tRNA(Lys)、tRNA(Glu)和tRNA(Gln)摆动位置(U34)上尿苷的2-硫醇化。为线粒体tRNA(Lys)、tRNA(Glu)和tRNA(Gln)摆动位置5-牛磺酸甲基-2-硫尿苷(tm5s2U)的形成所必需。需要ATP来激活摆动碱基的C2原子。 {ECO:0000269|PubMed:15509579, ECO:0000269|PubMed:15944150, ECO:0000269|PubMed:16826519}.

组织特异性

Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain.

亚细胞定位

Mitochondrion

关键词

Alternative splicing ATP-binding Deafness Disease variant Disulfide bond Mitochondrion Non-syndromic deafness Nucleotide-binding Proteomics identification Reference proteome

外部链接

UniProt: O75648

NCBI Gene

GeneCards