TRMT2A Q8IZ69

tRNA (尿嘧啶-5-)-甲基转移酶同源蛋白A (EC 2.1.1.35) (mRNA (尿嘧啶-5-)-甲基转移酶 TRMT2A) (EC 2.1.1.-)

蛋白质信息 (UniProt)

tRNA (尿嘧啶-5-)-甲基转移酶同源蛋白A (EC 2.1.1.35) (mRNA (尿嘧啶-5-)-甲基转移酶 TRMT2A) (EC 2.1.1.-)

Q8IZ69

功能描述

S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). 主要催化细胞质tRNAs中54位尿苷(m5U54)的甲基化 (PubMed:31361898, PubMed:33799331). 也能够介导某些mRNAs中5-甲基尿苷的形成 (PubMed:34123281). {ECO:0000269|PubMed:31361898, ECO:0000269|PubMed:33799331, ECO:0000269|PubMed:34123281, ECO:0000269|PubMed:34556860}.

亚细胞定位

Cytoplasm, cytosol

关键词

3D-structure Alternative splicing Coiled coil Cytoplasm Methyltransferase mRNA processing Phosphoprotein Proteomics identification Reference proteome RNA-binding

外部链接

UniProt: Q8IZ69

NCBI Gene

GeneCards