TRIB3 Q96RU7

Tribbles同源蛋白3 (TRB-3) (神经细胞死亡诱导推定激酶) (SINK) (p65相互作用NF-κB抑制剂)

功能描述

无活性的蛋白激酶，作为综合应激反应（ISR）的调节因子，这是一种适应各种应激的过程 (PubMed:15775988, PubMed:15781252)。抑制DDIT3/CHOP的转录活性，并参与内质网应激期间依赖DDIT3/CHOP的细胞死亡 (PubMed:15775988, PubMed:15781252)。可能在程序性神经元细胞死亡中发挥作用，但似乎不影响非神经元细胞 (PubMed:15775988, PubMed:15781252)。作为ISR期间ATF4依赖性转录的负反馈调节因子：虽然TRIB3的表达受ATF4促进，但TRIB3蛋白与ATF4相互作用并抑制ATF4的转录活性 (By similarity)。通过直接结合Akt激酶并阻断其激活来干扰胰岛素信号传导 (By similarity)。可能直接结合并掩盖AKT1中的'Thr-308'磷酸化位点 (By similarity)。与NF-kappa-B反式激活因子p65 RELA相互作用，抑制其磷酸化，从而抑制其转录激活活性 (PubMed:12736262)。与MAPK激酶相互作用并调节MAP激酶的激活 (PubMed:15299019)。能抑制APOBEC3A对核DNA的编辑 (PubMed:22977230)。 {ECO:0000250|UniProtKB:Q8K4K2, ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}。

组织特异性

Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.

亚细胞定位

Nucleus