色氨酸酶α/β-1 (色氨酸酶-1) (EC 3.4.21.59) (色氨酸酶 I) (色氨酸酶α-1)
色氨酸酶α/β-1 (色氨酸酶-1) (EC 3.4.21.59) (色氨酸酶 I) (色氨酸酶α-1)
Q15661功能描述
Tryptase是存在于肥大细胞中的主要中性蛋白酶，并在该细胞类型的偶联激活-脱颗粒反应中分泌。可能在先天免疫中发挥作用。Isoform 2切割大底物（如fibronectin）的效率比isoform 1更高，但对小底物的效率似乎较低 (PubMed:18854315)。 {ECO:0000250, ECO:0000250|UniProtKB:P21845, ECO:0000269|PubMed:18854315}.
组织特异性
Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).
亚细胞定位
Secreted. Note=Released from the secretory granules upon mast cell activation.
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