原肌球蛋白α-4链 (TM30p1) (原肌球蛋白-4)
原肌球蛋白α-4链 (TM30p1) (原肌球蛋白-4)
P67936功能描述
结合肌肉和非肌肉细胞中的肌动蛋白丝。与肌钙蛋白复合物协同，在脊椎动物横纹肌收缩的钙依赖性调节中发挥核心作用。平滑肌收缩通过与钙调蛋白的相互作用进行调节。在非肌肉细胞中，参与稳定细胞骨架肌动蛋白丝（根据相似性）。结合钙 (PubMed:1836432)。在血小板生成中发挥作用。 {ECO:0000250|UniProtKB:P09495, ECO:0000269|PubMed:1836432, ECO:0000269|PubMed:28134622, ECO:0000269|PubMed:35170221}。
组织特异性
Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).
亚细胞定位
Cytoplasm, cytoskeleton
关键词