TOPORS Q9NS56

E3泛素蛋白连接酶Topors (EC 2.3.2.27) (RING型E3泛素转移酶Topors) (SUMO1-蛋白E3连接酶Topors) (拓扑异构酶I结合RING指蛋白) (拓扑异构酶I结合精氨酸/丝氨酸富集蛋白) (肿瘤抑制蛋白p53结合蛋白3) (p53结合蛋白3) (p53BP3)

功能描述

具有E3泛素-protein连接酶和E3 SUMO1-protein连接酶的功能。可能的肿瘤抑制因子，参与细胞生长、细胞增殖和细胞凋亡，通过泛素依赖性降解调节p53/TP53稳定性。可能通过对几种染色质修饰相关蛋白的类泛素化修饰来调节染色质修饰。可能通过IKBKE的类泛素化修饰参与DNA损伤诱导的细胞死亡。 {ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15735665, ECO:0000269|PubMed:16122737, ECO:0000269|PubMed:17803295, ECO:0000269|PubMed:18077445, ECO:0000269|PubMed:19473992, ECO:0000269|PubMed:20188669}。

组织特异性

Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers.

亚细胞定位

Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.