TOP6BL Q8N6T0

2型DNA拓扑异构酶6亚基B样 (TOP6B like initiator of meiotic double strand breaks) (2型DNA拓扑异构酶VI亚基B样) (TOPOVIBL)

蛋白质信息 (UniProt)

2型DNA拓扑异构酶6亚基B样 (TOP6B like initiator of meiotic double strand breaks) (2型DNA拓扑异构酶VI亚基B样) (TOPOVIBL)

Q8N6T0

功能描述

[Isoform 3]: 拓扑异构酶6复合物的组分，特异性参与减数分裂重组。与SPO11一起，介导DNA切割，形成启动减数分裂重组的双链断裂(DSB)。该复合物通过切割和连接循环促进负超螺旋和正超螺旋DNA的松弛以及DNA去连环。 {ECO:0000250|UniProtKB:J3QMY9}。

组织特异性

Detected in lung, spleen,colon and in skeletal muscle. Expressed in the ovaries, Fallopian tubes and uterus (PubMed:30388401).

亚细胞定位

Chromosome

关键词

Alternative initiation Alternative splicing Chromosome Disease variant Meiosis Proteomics identification Reference proteome

UniProt: Q8N6T0

NCBI Gene

GeneCards