TOP2A P11388

DNA拓扑异构酶2-α (EC 5.6.2.2) (DNA拓扑异构酶II, α同工酶)

蛋白质信息 (UniProt)

DNA拓扑异构酶2-α (EC 5.6.2.2) (DNA拓扑异构酶II, α同工酶)

P11388

功能描述

关键解连环酶，通过结合两个双链DNA分子改变DNA拓扑结构，在其中一条链上产生双链断裂，使完整链穿过断裂链，并重新连接断裂链 (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612, PubMed:27754753)。可能在调节BMAL1转录振荡的周期长度方面发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612, ECO:0000269|PubMed:27754753}。

组织特异性

Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in high-grade lymphomas, squamous cell lung tumors and seminomas (PubMed:9155056).

亚细胞定位

Cytoplasm

关键词

3D-structure Acetylation Alternative splicing ATP-binding Biological rhythms Cytoplasm Direct protein sequencing DNA-binding Isomerase Isopeptide bond

外部链接

UniProt: P11388

NCBI Gene

GeneCards