TNS3 Q68CZ2

张力蛋白-3 (EC 3.1.3.-) (含SH2结构域张力蛋白样蛋白1) (肿瘤内皮标志物6)

功能描述

可能作为蛋白磷酸酶和/或脂质磷酸酶起作用 (Probable)。参与整合素-tensin-肌动蛋白复合物的解离 (PubMed:17643115)。EGF激活TNS4并下调TNS3，导致ITGB1尾部加帽 (PubMed:17643115)。增强DOCK5对Rac的鸟苷酸交换活性，并在破骨细胞伪足体组织中发挥作用 (By similarity)。在DLC1存在下增强RHOA激活 (PubMed:26427649)。生长因子诱导的上皮细胞迁移所必需；生长因子刺激诱导TNS3磷酸化，从而改变其结合偏好，从DLC1转变为PI3K激酶复合物的p85调节亚基，置换PI3K抑制剂PTEN，导致TNS3-p85复合物易位至迁移细胞的前沿以促进RAC1激活 (PubMed:26166433)。同时，PTEN转换结合偏好，从p85转变为DLC1，PTEN-DLC1复合物易位至迁移细胞的后部以激活RHOA (PubMed:26166433)。作为适配蛋白，通过桥接支架蛋白PEAK1与整合素ITGB1、ITGB3和ITGB5的关联，促进细胞迁移 (PubMed:35687021)。通过调节整合素ITGB1的活性，控制扁桃体来源的间充质干细胞的增殖和分化 (PubMed:31905841)。 {ECO:0000250|UniProtKB:Q5SSZ5, ECO:0000269|PubMed:17643115, ECO:0000269|PubMed:26166433, ECO:0000269|PubMed:26427649, ECO:0000269|PubMed:31905841, ECO:0000269|PubMed:35687021, ECO:0000305}。

组织特异性

Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed at higher levels in tonsil-derived mesenchymal stem cells (MSCs) than in adipose tissue-derived MSCs or bone marrow-derived MSCs (PubMed:31905841). Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.

亚细胞定位

Cell junction, focal adhesion