TNFAIP3相互作用蛋白1 (A20结合的NF-κB活化抑制剂1) (ABIN-1) (HIV-1 Nef相互作用蛋白) (Nef相关因子1) (Naf1) (Nip40-1) (病毒粒子相关核穿梭蛋白) (VAN) (hVAN)
TNFAIP3相互作用蛋白1 (A20结合的NF-κB活化抑制剂1) (ABIN-1) (HIV-1 Nef相互作用蛋白) (Nef相关因子1) (Naf1) (Nip40-1) (病毒粒子相关核穿梭蛋白) (VAN) (hVAN)
Q15025功能描述
通过调节TAX1BP1和A20/TNFAIP3介导的IKBKG去泛素化，抑制NF-kappa-B激活及TNF诱导的NF-kappa-B依赖性基因表达；推测其将A20/TNFAIP3连接至泛素化的IKBKG (PubMed:21885437)。参与EGF诱导的ERK1/ERK2信号通路调节；阻断MAPK3/MAPK1核转位及MAPK1依赖性转录。增加细胞表面CD4(T4)抗原表达。参与巨噬细胞的抗炎反应，并正向调节TLR诱导的CEBPB激活。参与自身免疫的预防；该功能涉及与多聚泛素的结合。参与炎症期间白细胞整合素的激活；该功能通过与SELPLG结合介导，并依赖于SRC家族激酶的磷酸化。与HIV-1基质蛋白相互作用，被包装进病毒颗粒，过表达可抑制病毒复制。可能调节基质核定位，包括病毒产生期间PIC（整合前复合体）的核输入以及GAG多聚蛋白和病毒基因组RNA的输出。在感染情况下，促进IKBKG与志贺氏菌(Shigella flexneri) E3泛素蛋白连接酶ipah9.8 p的结合，进而促进IKBKG的多聚泛素化，导致其依赖蛋白酶体的降解，从而扰乱细菌感染期间的NF-kappa-B激活。 {ECO:0000269|PubMed:12220502, ECO:0000269|PubMed:16684768, ECO:0000269|PubMed:17016622, ECO:0000269|PubMed:17632516, ECO:0000269|PubMed:20010814, ECO:0000269|PubMed:21885437}.
组织特异性
Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells.
亚细胞定位
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
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