肿瘤坏死因子配体超家族成员14 (疱疹病毒侵入介质配体) (HVEM-L) (疱疹病毒侵入介质配体) (CD抗原CD258) [剪切为：肿瘤坏死因子配体超家族成员14，膜型；肿瘤坏死因子配体超家族成员14，可溶型]
肿瘤坏死因子配体超家族成员14 (疱疹病毒侵入介质配体) (HVEM-L) (疱疹病毒侵入介质配体) (CD抗原CD258) [剪切为：肿瘤坏死因子配体超家族成员14，膜型；肿瘤坏死因子配体超家族成员14，可溶型]
O43557功能描述
结合TNFRSF3/LTBR的细胞因子。与诱饵受体TNFRSF6B结合可调节其效应。作为TNFRSF14/HVEM的配体 (PubMed:10754304, PubMed:9462508)。与TNFRSF14/HVEM结合后，向T细胞传递共刺激信号，导致T细胞增殖和IFNG产生 (PubMed:10754304)。 {ECO:0000269|PubMed:10754304, ECO:0000269|PubMed:9462508}.
组织特异性
Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
亚细胞定位
[Tumor necrosis factor ligand superfamily member 14, membrane form]: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 14, soluble form]: Secreted.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
关键词