TNFRSF25 Q93038

肿瘤坏死因子受体超家族成员25 (Apo-3) (凋亡诱导受体AIR) (凋亡介导受体DR3) (凋亡介导受体TRAMP) (死亡受体3) (淋巴细胞相关死亡受体) (LARD) (WSL蛋白) (WSL-1蛋白)

功能描述

TNFSF12/APO3L/TWEAK的受体。直接与接头蛋白TRADD相互作用。介导NF-kappa-B的激活并诱导细胞凋亡。可能在调节淋巴细胞稳态中发挥作用。 {ECO:0000269|PubMed:8875942, ECO:0000269|PubMed:8994832, ECO:0000269|PubMed:9052839}。

组织特异性

Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.

亚细胞定位

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 9]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 11]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted.; SUBCELLULAR LOCATION: [Isoform 10]: Secreted.; SUBCELLULAR LOCATION: [Isoform 12]: Secreted.