TMIGD2 Q96BF3

跨膜免疫球蛋白结构域包含蛋白2 (CD28同源物) (免疫球蛋白富含脯氨酸受体1) (IGPR-1)

功能描述

功能：在细胞-细胞相互作用、细胞迁移和血管生成中发挥作用。通过与HHLA2相互作用，在TCR介导的激活背景下共刺激T细胞。通过AKT依赖性信号级联反应增强T细胞增殖和细胞因子产生。 {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}。

组织特异性

Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands of the uterus, ureter, fallopian tube epithelium, colonic epithelium, small bowl epithelium, stomach epithelium, including both chief and parietal cells, trophoblastic epithelium of placenta, and pancreatic acinar cells (at protein level). Consistently expressed in veins and arteries (at protein level). Not detected in thyroid, cerebellum, cerebral cortex and thymus (at protein level). Expressed in lymphoid organs, with highest levels in thymus, spleen, peripheral blood lymphocytes and liver. In the thymus, expressed in CD4+ and CD8+ single- and double-positive cells, but not in immature CD4- and CD8- double-negative cells (at protein level). In peripheral blood mononuclear cells, highly expressed on CD56+ or CD16+ natural killer cells and CD3+ T-cells(at protein level). Not detected on B-cells(at protein level). Expressed in tonsils (at protein level).

亚细胞定位

Cell membrane