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TMEM25 Q86YD3

跨膜蛋白25

蛋白质信息 (UniProt)

跨膜蛋白25

Q86YD3

功能描述

在神经元中,调节NMDA受体GRIN2B亚基的降解。在神经元兴奋性调节中发挥作用。 {ECO:0000269|PubMed:31424425}。

组织特异性

Expressed throughout the brain with higher levels in the pyramidal cell layer of the hippocampal CA1 and CA3 regions. Also highly expressed within the hippocampal dentate gyrus region and cerebellum and in scattered neurons in the cerebral cortex.

亚细胞定位

[Isoform 1]: Cell membrane

关键词

Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Endosome Glycoprotein Immunoglobulin domain Lysosome Membrane Proteomics identification