TMEM119 Q4V9L6

跨膜蛋白119 (成骨细胞诱导因子) (OBIF)

功能描述

在骨形成和正常骨矿化中发挥重要作用。促进成肌细胞分化为成骨细胞 (PubMed:20025746)。可能通过增强BMP2产生以及与BMP-RUNX2通路相互作用，诱导成肌细胞向成骨细胞的定向和分化。上调ATF4的表达，ATF4是一种在成骨细胞分化中起核心作用的转录因子。对于正常精子发生和睾丸晚期分化至关重要 (By similarity)。 {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}。

组织特异性

Expressed in brain microglia (at protein level) (PubMed:26250788). Detected in urine (at protein level) (PubMed:37453717). Elevated expression levels seen in the brain of patients with Alzheimer disease (PubMed:26250788). Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues (PubMed:26250788).

亚细胞定位

Cell membrane