Tomoregulin-2 (TR-2) (增生性息肉蛋白1) (具有EGF样和两个卵泡抑素样结构域的跨膜蛋白)
Tomoregulin-2 (TR-2) (增生性息肉蛋白1) (具有EGF样和两个卵泡抑素样结构域的跨膜蛋白)
Q9UIK5功能描述
可能是海马和中脑神经元的存活因子。脱落形式上调癌细胞增殖，可能是通过促进ERK1/2磷酸化。 {ECO:0000269|PubMed:10903839, ECO:0000269|PubMed:17942404}.
组织特异性
Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.
亚细胞定位
[Isoform 1]: Membrane
关键词