TLR9 Q9NR96

Toll样受体9 (CD抗原CD289)

功能描述

先天免疫和适应性免疫的关键组分 (PubMed:14716310)。TLRs (Toll样受体) 通过识别微生物特有的分子模式来控制宿主对病原体的免疫反应 (PubMed:14716310)。TLR9是一种核苷酸感应TLR，可被未甲基化的胞苷-磷酸-鸟苷 (CpG) 二核苷酸激活 (PubMed:14716310)。通过MYD88和TRAF6起作用，导致NF-kappa-B激活、细胞因子分泌和炎症反应 (PubMed:11564765, PubMed:17932028)。也通过ADCY7起作用，导致环二腺苷酸 (c-di-AMP) 合成和NLRP3炎症小体激活 (By similarity)。在防御全身性小鼠巨细胞病毒感染中发挥作用 (By similarity)。控制淋巴细胞对幽门螺杆菌感染的反应 (By similarity)。在CpG刺激下，诱导B细胞增殖、激活、存活和抗体产生 (PubMed:23857366)。 {ECO:0000250|UniProtKB:Q9EQU3, ECO:0000269|PubMed:11564765, ECO:0000269|PubMed:14716310, ECO:0000269|PubMed:17932028, ECO:0000269|PubMed:23857366}。

组织特异性

Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.

亚细胞定位

Endoplasmic reticulum membrane