TIAM1 Q13009

Rho鸟嘌呤核苷酸交换因子TIAM1 (T淋巴瘤侵袭和转移诱导蛋白1) (TIAM-1)

功能描述

鸟苷酸交换因子，激活RHO样蛋白并将细胞外信号连接到细胞骨架活动。激活RAC1、CDC42，并在较小程度上激活RHOA及其下游信号传导，以调节细胞粘附和细胞迁移等过程。{ECO:0000269|PubMed:20361982, ECO:0000269|PubMed:25684205}。

组织特异性

Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

亚细胞定位

Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.