酰基辅酶A硫酯酶 THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (羧基末端调节蛋白) (硫酯酶超家族成员4)
酰基辅酶A硫酯酶 THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (羧基末端调节蛋白) (硫酯酶超家族成员4)
Q5T1C6功能描述
对中长链（C14至C18）脂肪酰CoA底物具有酰基CoA硫酯酶活性，可能在线粒体脂肪酸代谢中发挥作用。在凋亡过程中发挥作用，可能通过其对AKT1活性的调节。根据PubMed:11598301，抑制AKT1磷酸化和活性。根据PubMed:17615157，通过促进AKT1磷酸化及其向质膜的转位来增强AKT1活性。 {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:17615157, ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19453107, ECO:0000269|PubMed:22871024}.
组织特异性
Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.
亚细胞定位
Cell membrane
关键词