返回首页

TEX15 Q9BXT5

睾丸表达蛋白15 (癌/睾丸抗原42) (CT42)

蛋白质信息 (UniProt)

睾丸表达蛋白15 (癌/睾丸抗原42) (CT42)

Q9BXT5

功能描述

精子发生过程中生殖细胞正常染色体联会和减数分裂重组所必需。减数分裂染色体上DMC1和RAD51焦点的形成所必需,提示其在DNA双链断裂修复中具有特异性作用 (By similarity)。雄性胚胎生殖细胞中PIWIL4-piRNA通路导向的转座子DNA甲基化和沉默的关键执行者 (By similarity)。PIWIL4-piRNA结合新生转座子转录本并与TEX15相互作用,这可能进而招募表观遗传沉默机制至转座子位点 (By similarity)。piRNA生物合成不需要 (By similarity)。 {ECO:0000250|UniProtKB:F8VPN2}。

组织特异性

Expressed in testis, predominantly in germ cells (PubMed:11279525, PubMed:26199321). Low expression, if any, in ovary (PubMed:11279525, PubMed:26199321). Also expressed in several cancers (PubMed:12704671).

亚细胞定位

Cytoplasm

关键词

Cytoplasm Differentiation Disease variant DNA damage DNA repair Meiosis Nucleus Proteomics identification Reference proteome RNA-mediated gene silencing