味觉受体2型成员14 (T2R14) (味觉受体B家族成员1) (TRB1)
味觉受体2型成员14 (T2R14) (味觉受体B家族成员1) (TRB1)
Q9NYV8功能描述
与Gustducin偶联的G蛋白偶联受体，在苦味感知中发挥作用 (PubMed:38600377, PubMed:38776963)。该受体的活性刺激GNAT3，激活gustducin G蛋白通路 (PubMed:38600377, PubMed:38776963)。可能通过抑制性G蛋白通路，在感知胃肠道内容物及其他口外组织的化学成分中发挥作用 (PubMed:38600377, PubMed:38776963)。 {ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}。
组织特异性
Highly expressed in cerebellum, pancreas, small intestine and thymus; also expressed in adipose, aorta, skin and tongue, but at significantly lower levels (PubMed:38600377). Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in testis (PubMed:16720576).
亚细胞定位
Membrane; Multi-pass membrane protein
关键词