TACC1 O75410

含酸性卷曲螺旋转化蛋白1 (胃癌抗原Ga55) (Taxin-1)

功能描述

参与核受体诱导的转录调控，包括T3甲状腺激素和全反式视黄酸通路 (PubMed:20078863)。可能促进受体的核定位 (PubMed:20078863)。可能参与在分化组织形成前促进细胞分裂的过程。 {ECO:0000269|PubMed:20078863}。

组织特异性

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.

亚细胞定位

Cytoplasm