TAAR6 Q96RI8

痕量胺相关受体6 (TaR-6) (痕量胺受体6) (痕量胺受体4) (TaR-4)

功能描述

嗅觉受体，特异性识别微量胺，如β-苯乙胺 (beta-PEA)。微量胺化合物在动物体液中富集，并作用于微量胺相关受体 (TAARs) 以引发种内和种间先天行为。Beta-PEA结合引起构象改变，从而通过G alpha蛋白的G(s)类 (GNAL或GNAS) 触发信号传导。 {ECO:0000250|UniProtKB:Q5QD13}。

组织特异性

Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta (PubMed:15329799). In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia (PubMed:15329799).

亚细胞定位

Cell membrane