SYMPK Q92797

Symplekin蛋白

功能描述

FUNCTION：支架蛋白，作为参与组蛋白mRNA 3'端加工的多分子复合物的组分发挥作用。紧密连接（TJ）斑的特异性组分，但可能不是唯一的连接组分。可能具有看家作用。参与pre-mRNA多聚腺苷酸化。增强SSU72磷酸酶活性。 {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}。

组织特异性

In testis, expressed in polar epithelia and Sertoli cells but not in vascular endothelia. The protein is detected in stomach, duodenum, pancreas, liver, fetal brain, carcinomas, lens-forming cells, fibroblasts, lymphocytes, lymphoma cells, erythroleukemia cells but not in endothelium of vessels, epidermis, intercalated disks, Purkinje fiber cells of the heart and lymph node.

亚细胞定位

Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Nucleus, nucleoplasm. Note=Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells. Colocalizes with HSF1 in nuclear stress bodies upon heat shock (PubMed:14707147).