STEAP4 Q687X5

金属还原酶 STEAP4 (EC 1.16.1.-) (前列腺六跨膜上皮抗原4) (前列腺六跨膜蛋白2) (肿瘤坏死因子α诱导蛋白9)

功能描述

整合膜蛋白，作为NADPH依赖性铁螯合物还原酶发挥功能，利用膜一侧的NADPH还原结合在膜另一侧的Fe(3+)螯合物。介导从NADPH到FAD，再到血红素，最后到Fe(3+)螯合物的连续跨膜电子转移 (PubMed:30337524)。也能将Cu(2+)还原为Cu(1+) (By similarity)。在全身代谢稳态中发挥作用，整合炎症和代谢反应 (By similarity)。与肥胖和胰岛素抵抗相关 (PubMed:18381574, PubMed:18430367)。通过调节炎症细胞因子参与炎症性关节炎 (PubMed:19660107)。抑制锚定非依赖性细胞增殖 (PubMed:19787193)。 {ECO:0000250|UniProtKB:Q923B6, ECO:0000269|PubMed:18381574, ECO:0000269|PubMed:18430367, ECO:0000269|PubMed:19660107, ECO:0000269|PubMed:19787193, ECO:0000269|PubMed:30337524}。

组织特异性

Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages.

亚细胞定位

Cell membrane