STEAP3 Q658P3

金属还原酶 STEAP3 (EC 1.16.1.-) (Dudulin-2) (前列腺六次跨膜上皮抗原3) (肿瘤抑制因子激活通路蛋白6) (hTSAP6) (pHyde) (hpHyde)

功能描述

整合膜蛋白，作为依赖NADPH的铁螯合物还原酶发挥功能，利用膜一侧的NADPH还原结合在膜另一侧的Fe(3+)螯合物 (PubMed:26205815)。介导从NADPH到FAD，再到血红素，最后到Fe(3+)螯合物的连续跨膜电子转移 (By similarity)。也能将Cu(2+)还原为Cu(1+) (By similarity)。在红细胞中介导有效的依赖转铁蛋白的铁摄取 (By similarity)。可能在p53/TP53下游发挥作用，连接细胞凋亡和细胞周期进程 (By similarity)。通过促进TCTP等蛋白质的分泌，间接参与外泌体分泌 (PubMed:15319436, PubMed:16651434)。 {ECO:0000250|UniProtKB:Q5RKL5, ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8CI59, ECO:0000269|PubMed:15319436, ECO:0000269|PubMed:16651434, ECO:0000269|PubMed:26205815}。

组织特异性

Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.

亚细胞定位

Endosome membrane