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ST3GAL3 Q11203

CMP-N-乙酰神经氨酸-β-1,4-半乳糖苷α-2,3-唾液酸转移酶 (EC 2.4.3.6) (β-半乳糖苷α-2,3-唾液酸转移酶 3) (α 2,3-ST 3) (Gal β-1,3(4) GlcNAc α-2,3 唾液酸转移酶) (N-乙酰乳糖胺苷α-2,3-唾液酸转移酶) (ST3Gal III) (ST3GalIII) (ST3N) (唾液酸转移酶 6)

蛋白质信息 (UniProt)

CMP-N-乙酰神经氨酸-β-1,4-半乳糖苷α-2,3-唾液酸转移酶 (EC 2.4.3.6) (β-半乳糖苷α-2,3-唾液酸转移酶 3) (α 2,3-ST 3) (Gal β-1,3(4) GlcNAc α-2,3 唾液酸转移酶) (N-乙酰乳糖胺苷α-2,3-唾液酸转移酶) (ST3Gal III) (ST3GalIII) (ST3N) (唾液酸转移酶 6)

Q11203

功能描述

催化糖蛋白和糖脂末端碳水化合物基团中存在的NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-、NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-和NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-序列的形成。对Gal-beta-1,3-GlcNAc活性最高,对Gal-beta-1,3-GalNAc活性最低。 {ECO:0000250|UniProtKB:P97325}。

组织特异性

Highly expressed in adult skeletal muscle and in all fetal tissues examined and to a much lesser extent in placenta, lung and liver.

亚细胞定位

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

关键词

Alternative splicing Disease variant Disulfide bond Epilepsy Glycoprotein Glycosyltransferase Golgi apparatus Intellectual disability Membrane Proteomics identification