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ST18 O60284

肿瘤抑制性18蛋白 (锌指蛋白387)

蛋白质信息 (UniProt)

肿瘤抑制性18蛋白 (锌指蛋白387)

O60284

功能描述

抑制因子,结合含有双部分元件的DNA序列,该元件由序列5'-AAAGTTT-3'的直接重复组成,中间间隔2-9个核苷酸。抑制靶启动子的基础转录活性 (By similarity)。抑制培养的乳腺癌细胞集落形成。 {ECO:0000250, ECO:0000269|PubMed:15489893}。

组织特异性

Detected at low levels in heart, liver, kidney, skeletal muscle, pancreas, testis, ovary and prostate. Detected at even lower levels in mammary epithelial cells and breast cancer cells.

亚细胞定位

Nucleus

关键词

3D-structure Coiled coil DNA-binding Metal-binding Nucleus Proteomics identification Reference proteome Repeat Repressor Transcription