丝氨酸消旋酶 (EC 5.1.1.18) (D-丝氨酸解氨酶) (D-丝氨酸脱水酶) (EC 4.3.1.18) (L-丝氨酸解氨酶) (L-丝氨酸脱水酶) (EC 4.3.1.17)
丝氨酸消旋酶 (EC 5.1.1.18) (D-丝氨酸解氨酶) (D-丝氨酸脱水酶) (EC 4.3.1.18) (L-丝氨酸解氨酶) (L-丝氨酸脱水酶) (EC 4.3.1.17)
Q9GZT4功能描述
催化L-丝氨酸合成D-丝氨酸 (PubMed:20106978, PubMed:23391306, PubMed:29277459)。D-丝氨酸是NMDA受体与谷氨酸的关键共激动剂。对L-丝氨酸和D-丝氨酸均具有脱水酶活性 (By similarity)。 {ECO:0000250|UniProtKB:Q9QZX7, ECO:0000269|PubMed:20106978, ECO:0000269|PubMed:23391306, ECO:0000269|PubMed:29277459}。
组织特异性
Expressed in the cerebellum, hippocampus, dorsolateral prefrontal cortex, and in motor neurons and glial cells of the lumbar spinal cord (at protein level) (PubMed:17880399, PubMed:24138986). Increased in the dorsolateral prefrontal cortex of schizophrenic patients (at protein level) (PubMed:17880399). Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei (PubMed:15193426). Expressed in heart, skeletal muscle, kidney, and liver (PubMed:15193426).
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