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SRD5A2 P31213

3-氧-5-α-类固醇 4-脱氢酶 2 (EC 1.3.1.22) (5 α-SR2) (SR type 2) (类固醇 5-α-还原酶 2) (S5AR 2) (II型 5-α 还原酶)

蛋白质信息 (UniProt)

3-氧-5-α-类固醇 4-脱氢酶 2 (EC 1.3.1.22) (5 α-SR2) (SR type 2) (类固醇 5-α-还原酶 2) (S5AR 2) (II型 5-α 还原酶)

P31213

功能描述

将睾酮 (T) 转化为5-α-双氢睾酮 (DHT),并将孕酮或皮质酮转化为其相应的5-α-3-氧类固醇。它在性分化和雄激素生理学中起核心作用。 {ECO:0000269|PubMed:10898110}。

组织特异性

Expressed in high levels in the prostate and many other androgen-sensitive tissues.

亚细胞定位

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane

关键词

3D-structure Differentiation Disease variant Endoplasmic reticulum Lipid metabolism Membrane Microsome NADP Oxidoreductase Proteomics identification