SPX Q9BT56

Spexin (NPQ) (神经肽Q) (Spexin激素) [切割为：Spexin-1；Spexin-2 (NPQ 53-70)]

功能描述

作为心血管和肾功能及伤害感受的关键调节因子发挥作用。也在能量代谢和储存中发挥作用。抑制肾上腺皮质细胞增殖，对皮质类固醇释放有轻微刺激作用（通过相似性）。{ECO:0000250}。; FUNCTION: [Spexin-1]: 作为甘丙肽受体GALR2和GALR3的配体发挥作用(PubMed:17284679, PubMed:24517231)。脑室内注射该肽引起动脉血压升高，心率和肾排泄降低，以及延迟的尿钠排泄。脑室内注射该肽引起抗伤害感受活性。也引起毒蕈碱样胃平滑肌收缩。腹腔注射该肽引起食物消耗和体重减少。抑制长链脂肪酸摄取进入脂肪细胞（通过相似性）。{ECO:0000250, ECO:0000269|PubMed:17284679, ECO:0000269|PubMed:24517231}。; FUNCTION: [Spexin-2]: 脑室内注射该肽引起心率降低，但动脉压无变化，尿流率增加。脑室内注射该肽引起抗伤害感受活性（通过相似性）。{ECO:0000250}。

组织特异性

Expressed in the type I glomic cells within the carotid body (at protein level). Expressed predominantly in pancreas, testis, kidney, brain and placenta. Expressed in submucosal layer of esophagus and stomach fundus.

亚细胞定位

Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide (PubMed:17284679, PubMed:19193193). Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum.