SPRY3 O43610

Sprouty同源蛋白3 (Spry-3) (Sprouty RTK信号拮抗剂3) (Sprouty3)

功能描述

抑制神经突分支、树突长度和神经突复杂性 (By similarity)。抑制EGF介导的p42/44 ERK信号通路 (By similarity)。负向调节MAPK级联反应，导致细胞外基质蛋白积累减少 (PubMed:30878395)。可能作为成纤维细胞生长因子 (FGF) 通路的拮抗剂，并可能负向调节呼吸器官发生 (PubMed:9458049)。 {ECO:0000250|UniProtKB:Q3UUD2, ECO:0000269|PubMed:30878395, ECO:0000269|PubMed:9458049}。

组织特异性

Widely expressed; particularly in the fetal tissues. Expressed in the brain with expression the highest in Purkinje cells in the cerebellum (at protein level) (PubMed:26089202). Expressed in the myocardium of the heart (PubMed:30878395).

亚细胞定位

Cytoplasm.