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SPINK5 Q9NQ38

Kazal型丝氨酸蛋白酶抑制剂5 (淋巴上皮Kazal型相关抑制剂) (LEKTI) [切割为: 血滤肽HF6478; 血滤肽HF7665]

蛋白质信息 (UniProt)

Kazal型丝氨酸蛋白酶抑制剂5 (淋巴上皮Kazal型相关抑制剂) (LEKTI) [切割为: 血滤肽HF6478; 血滤肽HF7665]

Q9NQ38

功能描述

丝氨酸蛋白酶抑制剂,可能对粘膜上皮的抗炎和/或抗菌保护很重要。通过调节防御激活和参与脱屑的蛋白酶的活性,有助于皮肤的完整性和保护屏障功能。以pH依赖的方式抑制其主要靶点KLK5。抑制KLK7、KLK14、CASP14和胰蛋白酶。 {ECO:0000269|PubMed:10419450, ECO:0000269|PubMed:17596512, ECO:0000269|PubMed:20533828}。

组织特异性

Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate.

亚细胞定位

Secreted.

关键词

3D-structure Alternative splicing Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hypotrichosis Ichthyosis Protease inhibitor Proteomics identification Reference proteome