SPEG Q15772

条纹肌优先表达蛋白激酶 (EC 2.7.11.1) (主动脉优先表达蛋白1) (APEG-1)

功能描述

Isoform 3可能在调节动脉平滑肌细胞的生长和分化中起作用。

组织特异性

Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis.

亚细胞定位

[Isoform 3]: Nucleus.