SPATA13 Q96N96

精子发生相关蛋白13 (APC刺激的鸟嘌呤核苷酸交换因子2) (Asef2)

功能描述

作为RHOA、RAC1和CDC42 GTPases的鸟嘌呤核苷酸交换因子(GEF)。通过RAC1、PI3K、RHOA和AKT1依赖性机制调节细胞迁移及粘附组装与解组装。增加RAC1和CDC42活性，但降低活性RHOA的量。在结直肠肿瘤细胞中，通过JNK信号通路参与MMP9的上调。参与肿瘤血管生成，并可能在肠腺瘤形成和肿瘤进展中发挥作用。 {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}。

组织特异性

Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors.

亚细胞定位

Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cell projection, podosome