SP1 P08047

转录因子Sp1

功能描述

转录因子，能够响应生理和病理刺激激活或抑制转录。以高亲和力结合富含GC的基序，并调节大量参与细胞生长、细胞凋亡、分化及免疫反应等多种过程的基因表达。受到翻译后修饰（磷酸化、类泛素化、蛋白水解切割、糖基化和乙酰化）的高度调控。亦结合PDGFR-alpha G-box启动子。可能在调节细胞对DNA损伤的反应中发挥作用。参与染色质重塑。在FE65基因表达的调控中起重要作用。与ATF7IP形成复合物，通过诱导TERT和TERC基因表达来维持癌细胞中的端粒酶活性。Isoform 3是比isoform 1更强的转录激活因子。正调控核心时钟组分BMAL1的转录 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247)。在SMARCA4/BRG1募集至c-FOS启动子的过程中发挥作用。通过调节RNF112的表达，在脑损伤后保护细胞免受氧化应激损伤方面发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714, ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21046154, ECO:0000269|PubMed:21798247}.

组织特异性

Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels.

亚细胞定位

Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.