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SOST Q9BQB4

硬化蛋白

蛋白质信息 (UniProt)

硬化蛋白

Q9BQB4

功能描述

骨生长的负调节因子，通过抑制Wnt信号传导和骨形成发挥作用。 {ECO:0000269|PubMed:15908424}。

组织特异性

Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).

亚细胞定位

Secreted, extracellular space, extracellular matrix

关键词

3D-structure Alternative splicing Direct protein sequencing Disease variant Disulfide bond Extracellular matrix Glycoprotein Heparin-binding Proteomics identification Reference proteome

外部链接

UniProt: Q9BQB4
NCBI Gene