SORT1 Q99523

Sortilin (100 kDa NT受体) (糖蛋白95) (Gp95) (神经降压肽受体3) (NT3) (NTR3)

功能描述

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125, ECO:0000269|PubMed:11331584, ECO:0000269|PubMed:11390366, ECO:0000269|PubMed:12209882, ECO:0000269|PubMed:12598608, ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:14985763, ECO:0000269|PubMed:15313463, ECO:0000269|PubMed:15930396, ECO:0000269|PubMed:15987945, ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18817523}. (Wait, I should translate the text inside. The prompt asks to translate the description from English to Chinese. I should not just copy the English text. My thought process above was analyzing the constraints. I will now generate the Chinese translation.) FUNCTION: 在高尔基体区室作为分选受体，在细胞表面作为清除受体发挥作用。通过不依赖甘露糖-6-磷酸受体 (M6PR) 的途径，将protein从高尔基体转运至溶酶体所必需的。溶酶体protein特异性结合高尔基体中的受体，生成的受体-配体复合物被转运至酸性的前溶酶体区室，其中低pH值介导复合物的解离 (PubMed:16787399)。随后受体通过与retrmer结合回收至高尔基体进行下一轮运输。也是protein从高尔基体转运至内体所必需的。通过介导BDNF (proBDNF) 和 NGFB (proNGFB) 的促凋亡前体形式的内吞作用促进神经元凋亡。也作为神经降压素的受体发挥作用。可能通过清除细胞外LPL在成骨分化过程中促进细胞外基质的矿化。脂肪细胞中形成含有葡萄糖转运蛋白SLC2A4/GLUT4 (GLUT4储存囊泡，或GSVs) 的特化储存囊泡可能需要该蛋白。这些囊泡提供稳定的SLC2A4库并赋予对胰岛素增加的反应性。也可能介导从内质网到高尔基体的转运。 {ECO:0000269|PubMed:10085125, ECO:0000269|PubMed:11331584, ECO:0000269|PubMed:11390366, ECO:0000269|PubMed:12209882, ECO:0000269|PubMed:12598608, ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:14985763, ECO:0000269|PubMed:15313463, ECO:0000269|PubMed:15930396, ECO:0000269|PubMed:15987945, ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18817523}. Refining "protein": The prompt says "protein... retain English or use standard Chinese name". "Protein" -> "蛋白质" is standard. I will use "蛋白质". Refining "retromer": Standard Chinese is "逆转录酶" (incorrect in this context) or "分选蛋白复合体" / "逆转录复合体". "Retromer" is usually "逆转录复合体" or "retromer复合体". Let's use "逆转录复合体". Refining "neurotensin": "神经降压素". Refining "endocytosis": "内吞作用". Refining "proapoptotic": "促凋亡". Refining "osteogenic differentiation": "成骨分化". Refining "scavenging": "清除". Refining "adipocytes": "脂肪细胞". Refining "mineralization": "矿化". Final check of the output. FUNCTION: 在高尔基体区室作为分选受体，在细胞表面作为清除受体发挥作用。通过不依赖甘露糖-6-磷酸受体 (M6PR) 的途径，将蛋白质从高尔基体转运至溶酶体所必需的。溶酶体蛋白质特异性结合高尔基体中的受体，生成的受体-配体复合物被转运至酸性的前溶酶体区室，其中低pH值介导复合物的解离 (PubMed:16787399)。随后受体通过与逆转录复合体结合回收至高尔基体进行下一轮运输。也是蛋白质从高尔基体转运至内体所必需的。通过介导BDNF (proBDNF) 和 NGFB (proNGFB) 的促凋亡前体形式的内吞作用促进神经元凋亡。也作为神经降压素的受体发挥作用。可能通过清除细胞外LPL在成骨分化过程中促进细胞外基质的矿化。脂肪细胞中形成含有葡萄糖转运蛋白SLC2A4/GLUT4 (GLUT4储存囊泡，或GSVs) 的特化储存囊泡可能需要该蛋白。这些囊泡提供稳定的SLC2A4库并赋予对胰岛素增加的反应性。也可能介导从内质网到高尔基体的转运。 {ECO:0000269|PubMed:10085125, ECO:0000269|PubMed:11331584, ECO:0000269|PubMed:11390366, ECO:0000269|PubMed:12209882, ECO:0000269|PubMed:12598608, ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:14985763, ECO:0000269|PubMed:15313463, ECO:0000269|PubMed:15930396, ECO:0000269|PubMed:15987945, ECO:0000269|PubMed:16787399, ECO:0000269|PubMed:18817523}.

组织特异性

Expressed in brain and prostate (at protein level). Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver.

亚细胞定位

Golgi apparatus, Golgi stack membrane