SLURP2 P0DP57

分泌型Ly-6/uPAR结构域包含蛋白2 (分泌型LY6/PLAUR结构域包含蛋白2) (分泌型Ly-6/uPAR相关蛋白2) (SLURP-2)

功能描述

结合并可能调节烟碱型和毒蕈碱型乙酰胆碱受体的功能特性。可能调节角质形成细胞的增殖、分化和凋亡。体外实验中，中度抑制含alpha-3:beta-2的nAChRs的ACh诱发电流，强效抑制含alpha-4:beta-2的nAChRs的电流，调节含alpha-7的nAChRs，并抑制可能涉及含alpha-3:beta-4的nAChRs的尼古丁诱导信号。推测以正位方式作用于alpha-3:beta-2和alpha-7 nAChRs，以变构方式作用于mAChRs（如CHRM1和CHRM3）。 {ECO:0000269|PubMed:16575903, ECO:0000269|PubMed:27485575}。

组织特异性

Expressed at highest levels in cervix and esophagus, followed by adult and fetal skin. Expressed at lower levels in brain, lung, stomach, small intestine, colon, rectum, uterus, and thymus. Not detected in spleen nor bone marrow. Up-regulated 3-fold in psoriatic lesional skin (PubMed:12573258). In the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level) (PubMed:16575903). In attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level) (PubMed:16575903). Detected in serum (at protein level) (PubMed:16575903).

亚细胞定位

Secreted