SLCO1A2 P46721

溶质载体有机阴离子转运蛋白家族成员 1A2 (OATP1A2) (OATP-A) (有机阴离子转运多肽 1) (OATP-1) (非钠依赖性有机阴离子转运蛋白) (溶质载体家族 21 成员 3)

功能描述

不依赖Na(+)的转运蛋白，介导细胞摄取多种有机阴离子，如内源性胆汁盐胆酸盐和脱氧胆酸盐（以其非结合或结合形式，如牛磺胆酸盐和甘胆酸盐），该过程发生在质膜上 (PubMed:19129463, PubMed:7557095)。负责肠道对胆汁酸的吸收 (By similarity)。转运脱氢表雄酮3-硫酸盐(DHEAS)（肾上腺皮质分泌的主要循环类固醇），以及雌酮3-硫酸盐和17β-雌二醇17-O-(β-D-葡萄糖醛酸) (PubMed:11159893, PubMed:12568656, PubMed:19129463, PubMed:23918469, PubMed:25560245, PubMed:9539145)。介导全反式视黄醇(atROL)在人视网膜色素上皮顶端的摄取，这对维持视觉循环及视力的完整性至关重要 (PubMed:25560245)。参与临床常用药物的摄取 (PubMed:17301733, PubMed:20686826, PubMed:27777271)。能够转运甲状腺激素（包括T3或3,3',5'-三碘-L-甲状腺原氨酸，以及T4或L-甲状腺素） (PubMed:19129463, PubMed:20358049)。也转运前列腺素E2 (PubMed:19129463)。在有机阴离子和信号介质的血脑屏障及血脑脊液屏障转运，以及神经细胞摄取激素方面发挥作用 (By similarity)。可能也在视网膜神经元释放的神经肽（如P物质/TAC1和血管活性肠肽/VIP）的重摄取中发挥作用 (PubMed:25132355)。可能在结构多样的化疗药物甲氨蝶呤和紫杉醇的血浆和组织分布中起重要作用 (PubMed:23243220)。表现出pH敏感的底物特异性，这可能归因于结合位点的质子化状态，并导致在酸性微环境中底物转运受到刺激 (PubMed:19129463)。碳酸氢根/HCO3(-)充当可能的反向阴离子，与有机阴离子进行交换 (PubMed:19129463)。可能有助于调节睾丸中跨血睾屏障的有机化合物转运 (Probable)。 {ECO:0000250|UniProtKB:O88397, ECO:0000250|UniProtKB:Q91YY5, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:12568656, ECO:0000269|PubMed:17301733, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20358049, ECO:0000269|PubMed:20686826, ECO:0000269|PubMed:23243220, ECO:0000269|PubMed:23918469, ECO:0000269|PubMed:25132355, ECO:0000269|PubMed:25560245, ECO:0000269|PubMed:27777271, ECO:0000269|PubMed:7557095, ECO:0000269|PubMed:9539145, ECO:0000305|PubMed:35307651}.

组织特异性

Higher expression in the brain than in liver and kidney (PubMed:15632119, PubMed:7557095, PubMed:9539145). Expressed in brain neurons in both cortex and hippocampus (PubMed:10873595, PubMed:25132355). Expressed in placental trophoblasts (PubMed:12409283). Also expressed in lung and testes at lower levels (PubMed:7557095). Expressed in the eye (at protein level) (PubMed:25560245). Expressed in the retina in the outer and inner nuclear layers, the inner plexiform layer and the ganglion cell layer (PubMed:25132355). Expressed in liver and prostate (PubMed:10873595). In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and within the tubules (PubMed:35307651). Expressed in fetal brain and liver (PubMed:10873595).

亚细胞定位

Cell membrane