SLC7A7 Q9UM01

Y+L氨基酸转运蛋白1 (单核细胞氨基酸通透酶2) (MOP-2) (溶质载体家族7成员7) (y(+)L型氨基酸转运蛋白1) (Y+LAT1) (y+LAT-1)

功能描述

与SLC3A2形成异二聚体，作为反向转运蛋白发挥功能，通过将阳离子氨基酸从细胞内输出并与中性氨基酸加钠离子交换来作为外排途径，并可能通过L-精氨酸的转运参与一氧化氮的合成 (PubMed:10080182, PubMed:10655553, PubMed:14603368, PubMed:15756301, PubMed:15776427, PubMed:17329401, PubMed:9829974, PubMed:9878049)。也在非极性细胞（如单核细胞）中介导精氨酸转运，并且对这些细胞的正常功能至关重要 (PubMed:15280038, PubMed:31705628)。转运机制是电中性的，并以1:1的化学计量比运作 (By similarity)。在体外，Na(+)和Li(+)以及H(+)与中性氨基酸协同转运 (By similarity)。 {ECO:0000250|UniProtKB:Q9R0S5, ECO:0000269|PubMed:10080182, ECO:0000269|PubMed:10655553, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:15776427, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:31705628, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}。

组织特异性

Highest expression in kidney and peripheral blood leukocytes (PubMed:9829974). Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine (PubMed:9829974). Expressed in normal fibroblasts and those from LPI patients (PubMed:10080183, PubMed:11078698). Also expressed in HUVECs, monocytes, retinal pigment epithelial cells, and various carcinoma cell lines, with highest expression in a colon-carcinoma cell line (PubMed:11742806, PubMed:15280038, PubMed:17197568, PubMed:17329401).

亚细胞定位

Basolateral cell membrane