大中性氨基酸转运蛋白小亚基1 (4F2轻链) (4F2 LC) (4F2LC) (CD98轻链) (整合膜蛋白E16) (E16) (L型氨基酸转运蛋白1) (hLAT1) (溶质载体家族7成员5) (y+系统阳离子氨基酸转运蛋白)
大中性氨基酸转运蛋白小亚基1 (4F2轻链) (4F2 LC) (4F2LC) (CD98轻链) (整合膜蛋白E16) (E16) (L型氨基酸转运蛋白1) (hLAT1) (溶质载体家族7成员5) (y+系统阳离子氨基酸转运蛋白)
Q01650功能描述
与SLC3A2形成的异二聚体作为不依赖钠离子的高亲和力转运蛋白，介导大分子中性氨基酸的摄取，如苯丙氨酸、酪氨酸、亮氨酸、组氨酸、甲硫氨酸、色氨酸、缬氨酸、异亮氨酸和丙氨酸 (PubMed:10049700, PubMed:10574970, PubMed:11557028, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:15769744, PubMed:18262359, PubMed:25998567, PubMed:30867591, PubMed:9751058)。与SLC3A2形成的异二聚体介导L-DOPA的摄取 (By similarity)。作为氨基酸交换蛋白发挥作用 (PubMed:11557028, PubMed:12117417, PubMed:12225859, PubMed:30867591)。可能在L-DOPA跨越血脑屏障的转运中发挥作用 (By similarity)。可能作为成纤维细胞中酪氨酸的主要转运蛋白 (Probable)。可能介导跨越内层血视网膜屏障的血液到视网膜L-亮氨酸转运 (By similarity)。能够介导甲状腺激素二碘甲状腺原氨酸 (T2)、三碘甲状腺原氨酸 (T3) 和甲状腺素 (T4) 跨越细胞膜的转运 (PubMed:11564694)。当与LAPTM4B结合时，由SLC3A2和SLC7A5形成的异二聚体被募集至溶酶体以促进亮氨酸摄取进入这些细胞器，从而介导mTORC1激活 (PubMed:25998567)。参与毒性甲基汞 (MeHg) 的摄取，当以L-半胱氨酸或D,L-同型半胱氨酸复合物形式给药时 (PubMed:12117417)。通过L-亚硝基半胱氨酸 (L-CNSO) 跨膜的立体选择性转运，参与小分子量亚硝基硫醇的细胞活性 (PubMed:15769744)。 {ECO:0000250|UniProtKB:Q63016, ECO:0000250|UniProtKB:Q9Z127, ECO:0000269|PubMed:10049700, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:18262359, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:9751058, ECO:0000305|PubMed:18262359}.; FUNCTION: (Microbial infection) 在丙型肝炎病毒/HCV感染的情况下，由SLC3A2和SLC7A5/LAT1形成的复合物通过促进病毒进入宿主细胞并增加L-亮氨酸摄取介导的mTORC1信号激活，在HCV增殖中发挥作用，从而促进HCV介导的致病机制。 {ECO:0000269|PubMed:30341327}.
组织特异性
Detected in placenta, in the syncytiotrophoblast layer (at protein level) (PubMed:11389679). Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.
亚细胞定位
Apical cell membrane
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