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SLC6A19 Q695T7

钠依赖性中性氨基酸转运蛋白 B(0)AT1 (溶质载体家族6成员19) (系统 B(0) 中性氨基酸转运蛋白 AT1)

蛋白质信息 (UniProt)

钠依赖性中性氨基酸转运蛋白 B(0)AT1 (溶质载体家族6成员19) (系统 B(0) 中性氨基酸转运蛋白 AT1)

Q695T7

功能描述

介导肾和小肠上皮细胞顶膜中性氨基酸重吸收的转运蛋白 (PubMed:15286787, PubMed:15286788, PubMed:18424768, PubMed:18484095, PubMed:19185582, PubMed:26240152)。这种摄取是钠依赖性和非氯依赖性的 (PubMed:15286787, PubMed:15286788, PubMed:19185582)。在肾脏需要CLTRN或在肠道需要ACE2才能实现细胞表面表达和氨基酸转运蛋白活性 (PubMed:18424768, PubMed:19185582)。 {ECO:0000269|PubMed:15286787, ECO:0000269|PubMed:15286788, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:18484095, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:26240152}。

组织特异性

Robust expression in kidney and small intestine, with minimal expression in pancreas (PubMed:15286787, PubMed:18424768). Also expressed in stomach, liver, duodenum, ileocecum, colon and prostate. Not detected in testis, whole brain, cerebellum, fetal liver, spleen, skeletal muscle, uterus, heart or lung.

亚细胞定位

Cell membrane

关键词

3D-structure Amino-acid transport Cell membrane Disease variant Glycoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Symport