SLC5A4 Q9NY91

推测葡萄糖传感器蛋白 SLC5A4 (溶质载体家族5成员4)

功能描述

不作为钠/D-葡萄糖同向转运蛋白发挥作用 (PubMed:13130073, PubMed:20421923, PubMed:22766068)。然而，可能作为D-葡萄糖传感器发挥作用，通过产生D-葡萄糖诱导的去极化，该去极化不依赖于pH，在中性pH下依赖于Na(+)，在酸性pH下可能依赖于H(+) (PubMed:13130073, PubMed:17110502, PubMed:20421923, PubMed:22766068)。 {ECO:0000269|PubMed:13130073, ECO:0000269|PubMed:17110502, ECO:0000269|PubMed:20421923, ECO:0000269|PubMed:22766068}。

组织特异性

Expressed in skeletal muscle, where it may localize to the neuromuscular junction (at protein level) (PubMed:13130073). Expressed in small intestine where it may localize to cholinergic neurons of the submucosal plexus and myenteric plexus (at protein level) (PubMed:13130073). Detected in kidney (at protein level) (PubMed:22766068).

亚细胞定位

Cell membrane