SLC4A8 Q2Y0W8

电中性碳酸氢钠交换蛋白 1 (电中性Na(+)驱动Cl-HCO3交换蛋白) (溶质载体家族4成员8) (k-NBC3)

功能描述

介导电中性的钠和碳酸根依赖性氯-HCO3(-)交换，Na(+):HCO3(-)化学计量比为2:1 (PubMed:18577713)。在神经元pH调节中起主要作用 (By similarity)。介导肾皮质集合管中的钠重吸收 (By similarity)。 {ECO:0000250|UniProtKB:Q8JZR6, ECO:0000269|PubMed:18577713}。

组织特异性

Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex.

亚细胞定位

Apical cell membrane