SLC47A1 Q96FL8

多药和毒素外排蛋白 1 (MATE-1) (hMATE-1) (溶质载体家族47成员1)

功能描述

多药外排泵，作为H(+)/有机阳离子反向转运体发挥作用 (PubMed:16330770, PubMed:17509534)。在通过肾脏和肝脏分别将阳离子化合物（包括内源性代谢物、药物、毒素）排入尿液和胆汁的过程中发挥生理作用 (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373)。介导内源性化合物如肌酐、维生素B1/硫胺素、鲱精胺和雌酮-3-硫酸盐的外排 (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373)。可能也有助于调节睾丸中跨血睾屏障的阳离子化合物转运 (Probable)。 {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:17495125, ECO:0000269|PubMed:17509534, ECO:0000269|PubMed:17582384, ECO:0000269|PubMed:18305230, ECO:0000269|PubMed:19158817, ECO:0000269|PubMed:21128598, ECO:0000269|PubMed:24961373, ECO:0000305|PubMed:35307651}。

组织特异性

Widely expressed. The highest expression is found in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney. In testis, primarily localized throughout the adluminal compartment of the seminiferous tubules with expression at the peritubular myoid cells and Leydig cells (PubMed:35307651).

亚细胞定位

Cell membrane