大中性氨基酸转运蛋白小亚基4 (L型氨基酸转运蛋白4) (溶质载体家族43成员2)
大中性氨基酸转运蛋白小亚基4 (L型氨基酸转运蛋白4) (溶质载体家族43成员2)
Q8N370功能描述
单向转运蛋白，介导立体特异性的L-苯丙氨酸、L-甲硫氨酸和L-支链氨基酸在细胞外空间与细胞质之间的运输，并可能控制肾脏和小肠中中性氨基酸的跨上皮（重）吸收 (PubMed:15659399, PubMed:30379325)。转运活性通过协助扩散进行，且不依赖于钠离子、氯离子和pH (PubMed:15659399)。 {ECO:0000269|PubMed:15659399, ECO:0000269|PubMed:30379325}。
组织特异性
Detected in several tissues with higher expression in placenta, kidney and peripheral blood leukocytes (PubMed:15659399). In the kidney, is detected in epithelial cells of the distal tubule and collecting duct (PubMed:15659399). In the intestine, is expressed mainly in crypt cells of the intestinal microvilli and epithelial cells in the base of the villus (PubMed:15659399).
亚细胞定位
Cell membrane
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