SLC41A1 Q8IVJ1

溶质载体家族41成员1

功能描述

Na(+)/Mg(2+)离子交换蛋白，作为细胞膜上主要的Mg(2+)外排系统(PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986)。转运蛋白活性由内向的Na(+)离子电化学梯度驱动，因此直接依赖于由Na(+)/K(+)泵设定的细胞外Na(+)离子浓度(PubMed:22031603, PubMed:23661805)。产生昼夜节律性细胞Mg(2+)流，反馈调节时钟控制的基因表达和代谢，并促进白天更高的能量需求(PubMed:27074515)。在调节ATP依赖性酶（包括在三羧酸循环和电子传递链中起作用的酶）的活性方面具有作用(By similarity)。 {ECO:0000250|UniProtKB:Q8BJA2, ECO:0000269|PubMed:18367447, ECO:0000269|PubMed:22031603, ECO:0000269|PubMed:23661805, ECO:0000269|PubMed:23976986, ECO:0000269|PubMed:27074515}.

组织特异性

Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen. In the kidney, it is expressed in the distal convoluted tubules, macula densa, and thick ascending limb tubular segments of the nephrons (PubMed:23661805).

亚细胞定位

Cell membrane