SLC38A8 A6NNN8

溶质载体家族38成员8 (氨基酸转运蛋白SLC38A8)

功能描述

电致性钠依赖性氨基酸转运蛋白，偏好L-谷氨酰胺、L-丙氨酸、L-组氨酸、L-天冬氨酸和L-精氨酸。可能促进兴奋性和抑制性神经元中谷氨酰胺的摄取。转运机制和化学计量尚待阐明。{ECO:0000250|UniProtKB:Q5HZH7}。

组织特异性

Expressed in fetal and adult brain, and spinal cord. In the brain, it is localized in the cell body and axon of the majority of neuronal cells and in a subset of glial cells. Found throughout the neuronal retina, with higher expression levels in the inner and outer plexiform layers and the photoreceptor layer. Very weak expression is also present in the kidneys, thymus, and testes.

亚细胞定位

Membrane