SLC2A5 P22732

溶质载体家族2，易化葡萄糖转运蛋白成员5 (果糖转运蛋白) (葡萄糖转运蛋白5型，小肠) (GLUT-5)

功能描述

作为一种果糖转运蛋白发挥作用，对其他单糖的活性很低 (PubMed:16186102, PubMed:17710649, PubMed:28083649, PubMed:29548810, PubMed:8333543)。能够介导2-脱氧葡萄糖的摄取，但效率较低 (PubMed:1695905)。对于小肠中的果糖摄取至关重要 (By similarity)。在响应膳食果糖调节盐摄取和血压方面发挥作用 (By similarity)。高膳食果糖摄入引起的高血压发展所必需的 (By similarity)。 {ECO:0000250|UniProtKB:Q9WV38, ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:17710649, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:29548810, ECO:0000269|PubMed:8333543}。

组织特异性

Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

亚细胞定位

Apical cell membrane